Antiviral properties of Essential Oils: What do we know?
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Abstract
This narrative review delves into the antiviral properties of essential oils and aromatherapy, a field gaining prominence recently. Essential oils are noted for their pharmacological effects, particularly their antiviral capabilities. The review pays special attention to essential oils' effectiveness against influenza and coronaviruses. A comprehensive review in this context underscores the diverse chemical compounds in essential oils that offer broad-spectrum antiviral mechanisms. This is crucial given the growing resistance to conventional antiviral drugs, positioning plant-derived essential oils as potential novel antiviral agents. The hypothesis posited in this review is that essential oils could be effective natural antiviral agents, potentially useful as complementary or alternative therapies in viral infections. The review underscores the significance of essential oils' antiviral properties in enhancing human health, advocating for more focused research in this area.
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Wani AR, Yadav K, Khursheed A, Rather MA. An updated and comprehensive review of the antiviral potential of essential oils and their chemical constituents with special focus on their mechanism of action against various influenza and coronaviruses. Microb Pathog. 2021 Mar;152:104620. doi: 10.1016/j.micpath.2020.104620. Epub 2020 Nov 16. PMID: 33212200; PMCID: PMC9159739.
Ma L, Yao L. Antiviral Effects of Plant-Derived Essential Oils and Their Components: An Updated Review. Molecules. 2020 Jun 5;25(11):2627. doi: 10.3390/molecules25112627. PMID: 32516954; PMCID: PMC7321257.
Reichling J. Antiviral and Virucidal Properties of Essential Oils and Isolated Compounds - A Scientific Approach. Planta Med. 2022 Jul;88(8):587-603. doi: 10.1055/a-1382-2898. Epub 2021 Jun 18. PMID: 34144626. DOI: https://doi.org/10.1055/a-1382-2898
Wani AR, Yadav K, Khursheed A, Rather MA. An updated and comprehensive review of the antiviral potential of essential oils and their chemical constituents with special focus on their mechanism of action against various influenza and coronaviruses. Microb Pathog. 2021 Mar;152:104620. doi: 10.1016/j.micpath.2020.104620. Epub 2020 Nov 16. PMID: 33212200; PMCID: PMC9159739. DOI: https://doi.org/10.1016/j.micpath.2020.104620
Ma L, Yao L. Antiviral Effects of Plant-Derived Essential Oils and Their Components: An Updated Review. Molecules. 2020 Jun 5;25(11):2627. doi: 10.3390/molecules25112627. PMID: 32516954; PMCID: PMC7321257. DOI: https://doi.org/10.3390/molecules25112627
Corrêa ANR, Weimer P, Rossi RC, Hoffmann JF, Koester LS, Suyenaga ES, Ferreira CD. Lime and orange essential oils and d-limonene as a potential COVID-19 inhibitor: Computational, in chemico, and cytotoxicity analysis. Food Biosci. 2023 Feb;51:102348. doi: 10.1016/j.fbio.2022.102348. Epub 2022 Dec 30. PMID: 36597499; PMCID: PMC9801698. DOI: https://doi.org/10.1016/j.fbio.2022.102348
de Sousa DP, Damasceno ROS, Amorati R, Elshabrawy HA, de Castro RD, Bezerra DP, Nunes VRV, Gomes RC, Lima TC. Essential Oils: Chemistry and Pharmacological Activities. Biomolecules. 2023 Jul 18;13(7):1144. doi: 10.3390/biom13071144. PMID: 37509180; PMCID: PMC10377445. DOI: https://doi.org/10.3390/biom13071144
Amparo TR, Seibert JB, Silveira BM, Costa FSF, Almeida TC, Braga SFP, da Silva GN, Dos Santos ODH, de Souza GHB. Brazilian essential oils as source for the discovery of new anti-COVID-19 drug: a review guided by in silico study. Phytochem Rev. 2021;20(5):1013-1032. doi: 10.1007/s11101-021-09754-4. Epub 2021 Apr 13. PMID: 33867898; PMCID: PMC8042356. DOI: https://doi.org/10.1007/s11101-021-09754-4
Iqhrammullah M, Rizki DR, Purnama A, Duta TF, Harapan H, Idroes R, Ginting B. Antiviral Molecular Targets of Essential Oils against SARS-CoV-2: A Systematic Review. Scientia Pharmaceutica. 2023; 91(1):15. DOI: https://doi.org/10.3390/scipharm91010015
Bachar SC, Mazumder K, Bachar R, Aktar A, Al Mahtab M. A Review of Medicinal Plants with Antiviral Activity Available in Bangladesh and Mechanistic Insight Into Their Bioactive Metabolites on SARS-CoV-2, HIV and HBV. Front Pharmacol. 2021 Nov 8;12:732891. doi: 10.3389/fphar.2021.732891. PMID: 34819855; PMCID: PMC8606584. DOI: https://doi.org/10.3389/fphar.2021.732891
Wilkin PJ, Al-Yozbaki M, George A, Gupta GK, Wilson CM. The Undiscovered Potential of Essential Oils for Treating SARS-CoV-2 (COVID-19). Curr Pharm Des. 2020;26(41):5261-5277. doi: 10.2174/1381612826666201015154611. PMID: 33059564. DOI: https://doi.org/10.2174/1381612826666201015154611
Wu S, Patel KB, Booth LJ, Metcalf JP, Lin HK, Wu W. Protective essential oil attenuates influenza virus infection: an in vitro study in MDCK cells. BMC Complement Altern Med. 2010 Nov 15;10:69. doi: 10.1186/1472-6882-10-69. PMID: 21078173; PMCID: PMC2994788. DOI: https://doi.org/10.1186/1472-6882-10-69
Mieres-Castro D, Ahmar S, Shabbir R, Mora-Poblete F. Antiviral Activities of Eucalyptus Essential Oils: Their Effec-tiveness as Therapeutic Targets against Human Viruses. Pharmaceuticals (Basel). 2021 Nov 23;14(12):1210. doi: 10.3390/ph14121210. PMID: 34959612; PMCID: PMC8706319. DOI: https://doi.org/10.3390/ph14121210
Schnitzler P. Essential Oils for the Treatment of Herpes Simplex Virus Infections. Chemotherapy. 2019;64(1):1-7. doi: 10.1159/000501062. Epub 2019 Jun 24. PMID: 31234166. DOI: https://doi.org/10.1159/000501062
Cunningham AL, Diefenbach RJ, Miranda-Saksena M, Bosnjak L, Kim M, Jones C, Douglas MW. The cycle of human herpes simplex virus infection: virus transport and immune control. J Infect Dis. 2006 Sep 15;194 Suppl 1:S11-8. doi: 10.1086/505359. PMID: 16921466. DOI: https://doi.org/10.1086/505359
Ćavar Zeljković S, Schadich E, Džubák P, Hajdúch M, Tarkowski P. Antiviral Activity of Selected Lamiaceae Essential Oils and Their Monoterpenes Against SARS-Cov-2. Front Pharmacol. 2022 May 2;13:893634. doi: 10.3389/fphar.2022.893634. PMID: 35586050; PMCID: PMC9108200. DOI: https://doi.org/10.3389/fphar.2022.893634
El Gendy AEG, Essa AF, El-Rashedy AA, Elgamal AM, Khalaf DD, Hassan EM, Abd-ElGawad AM, Elgorban AM, Zaghloul NS, Alamery SF, Elshamy AI. Antiviral Potentialities of Chemical Characterized Essential Oils of Acacia nilotica Bark and Fruits against Hepatitis A and Herpes Simplex Viruses: In Vitro, In Silico, and Molecular Dynamics Studies. Plants (Basel). 2022 Oct 28;11(21):2889. doi: 10.3390/plants11212889. PMID: 36365342; PMCID: PMC9656187. DOI: https://doi.org/10.3390/plants11212889
Damiescu R, Lee DYW, Efferth T. Can Essential Oils Provide an Alternative Adjuvant Therapy for COVID-19 Infections and Pain Management at the Same Time? Pharmaceuticals (Basel). 2022 Nov 10;15(11):1387. doi: 10.3390/ph15111387. PMID: 36355558; PMCID: PMC9693097. DOI: https://doi.org/10.3390/ph15111387
Torres Neto L, Monteiro MLG, Galvan D, Conte-Junior CA. An Evaluation of the Potential of Essential Oils against SARS-CoV-2 from In Silico Studies through the Systematic Review Using a Chemometric Approach. Pharmaceuticals (Basel). 2021 Nov 10;14(11):1138. doi: 10.3390/ph14111138. PMID: 34832920; PMCID: PMC8624289. DOI: https://doi.org/10.3390/ph14111138
Silva JKRD, Figueiredo PLB, Byler KG, Setzer WN. Essential Oils as Antiviral Agents. Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation. Int J Mol Sci. 2020 May 12;21(10):3426. doi: 10.3390/ijms21103426. PMID: 32408699; PMCID: PMC7279430. DOI: https://doi.org/10.3390/ijms21103426